Volume 22, No 5, May 2012
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 22 Issue 5, May 2012: 793-805
REVIEWS
Polarized sorting and trafficking in epithelial cells
Xinwang Cao1,2, Michal A Surma1 and Kai Simons1
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
2School of life sciences, Anhui Medical University, Hefei, Anhui 230032, China
Correspondence: Kai Simons,(simons@mpi-cbg.de)
The polarized distribution of proteins and lipids at the surface membrane of epithelial cells results in the formation of an apical and a basolateral domain, which are separated by tight junctions. The generation and maintenance of epithelial polarity require elaborate mechanisms that guarantee correct sorting and vectorial delivery of cargo molecules. This dynamic process involves the interaction of sorting signals with sorting machineries and the formation of transport carriers. Here we review the recent advances in the field of polarized sorting in epithelial cells. We especially highlight the role of lipid rafts in apical sorting.
Cell Research (2012) 22:793-805. doi:10.1038/cr.2012.64; published online 24 April 2012
FULL TEXT | PDF
Browse 1930
