Volume 22, No 4, Apr 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 4, April 2012: 611-613

RESEARCH HIGHLIGHTS

Shh goes multidirectional in axon guidance

Paola Bovolenta and Luisa Sanchez-Arrones

Centro de Biolog韆 Molecular 揝evero Ochoa�, CSIC-UAM and CIBER de Enfermedades Raras (CIBERER), c/ Nicolas Cabrera, 1, Madrid 28049, Spain Correspondence: Paola Bovolenta,(pbovolenta@cbm.uam.es)

Shh and Wnts, secreted by the floor and roof plate of the spinal cord, direct longitudinal growth of the axons from the adjacent ventral funiculus and cortico-spinal tract. Whether these midline cues influence the directionality of axons elongating in more lateral positions of the spinal cord is unexplored. Song and colleagues investigate this possibility and demonstrate that the location of descending raphe-spinal tract in the ventrolateral spinal cord is dictated by the simultaneous repellent activity of Shh gradients in both the anterior-to-posterior (A-P) and medial-to-lateral (M-L) axis.

Cell Research (2012) 22:611-613. doi:10.1038/cr.2011.187; published online 22 November 2011

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