Volume 22, No 4, Apr 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 4, April 2012: 614-615

RESEARCH HIGHLIGHTS

Telomere length and iPSC re-programming: survival of the longest

Richard Allsopp

John A Burns School of Medicine, Institute for Biogenesis Research, University of Hawaii, 651 Ilalo St., Biomedical Science Bldg, Room 163B, Honolulu HI 96813, USA Correspondence: Richard Allsopp,(allsopp@hawaii.edu)

A hallmark feature of pluripotent stem cells is the ability to proliferate indefinitely (immortal phenotype). Despite reactivation of telomerase during iPSC derivation, there exists considerable heterogeneity in telomere length amongst established iPSC cell lines. Both telomerase-dependent and -independent mechanisms have now been shown to be important for continuous self-renewal of iPSC via the maintenance or extension of telomere length.

Cell Research (2012) 22:614-615. doi:10.1038/cr.2012.6; published online 3 January 2012

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