Volume 22, No 3, Mar 2012
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 22 Issue 3, March 2012: 447-449
RESEARCH HIGHLIGHTS
PKM2: A gatekeeper between growth and survival
Isaac Harris1,2, Susan McCracken1 and Tak Wah Mak1
1The Campbell Family Institute for Breast Cancer Research, 620 University Avenue, Toronto, ON M5C 2M9, Canada;
2The Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON M5G 2C1, Canada
Correspondence: Tak Wah Mak,(tmak@uhnres.utoronto.ca)
Pyruvate kinase catalyzes the transfer of a high-energy phosphate group from phosphoenol pyruvate (PEP) to generate pyruvate and ATP, a reaction that is the rate-limiting step of the glycolytic pathway. The PKM1 alternatively-spliced isoform is ubiquitously expressed whereas the PKM2 isoform is normally highly expressed only in embryos and undifferentiated tissues, correlating with high rates of cellular proliferation. Notably, tumors express the PKM2 form to the exclusion of the M1 isoform.
Cell Research (2012) 22:447-449. doi:10.1038/cr.2011.203; published online 20 December 2011
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