Volume 22, No 2, Feb 2012
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 22 Issue 2, February 2012: 277-279
RESEARCH HIGHLIGHTS
The Intestine: where amazing things happen
Nicola Gagliani1, Samuel Huber1,2 and Richard A Flavell1,3
1Department of Immunobiology, Yale University, School of Medicine, New Haven, CT 06520, USA;
2I. Medizinische Klinik, Universitaetsklinikum Hamburg-Eppendorf, 20246 Hamburg, Germany;
3Howard Hughes Medical Institute
Correspondence: Richard A Flavell,(Richard.flavell@yale.edu)
We all have been taught that the immune system is educated in the thymus; however, where the immune system receives the second lesson in order to be tolerant against non-harmful pathogens, such as commensal bacteria, has never been addressed. Considering that commensal bacteria colonize the intestine and that regulatory T (Treg) cells are enriched in this organ, one could think that the intestine is the place where this second lesson would occur. This idea was now sustained by the work of Lathrop et al., which sheds new light on the complex mechanism of peripheral tolerance induction.
Cell Research (2012) 22:277-279. doi:10.1038/cr.2011.204; published online 20 December 2011
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