Volume 22, No 2, Feb 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 2, February 2012: 280-282

RESEARCH HIGHLIGHTS

CTCF-cohesin complex: architect of chromatin structure regulates V(D)J rearrangement

Ann J Feeney and Jiyoti Verma-Gaur

The Scripps Research Institute, Department of Immunology and Microbial Science, IMM22, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA Correspondence: Ann J Feeney(feeney@scripps.edu)

The CTCF/cohesin complex regulates higher order chromatin structure by creating long-range chromatin loops and by insulating neighboring genes from each other. The lymphocyte antigen receptor loci have large numbers of CTCF/cohesin binding sites, and recent studies demonstrate that the CTCF/cohesin complex plays several important roles in regulating the process of V(D)J recombination at these megabase-sized receptor loci.

Cell Research (2012) 22:280-282. doi: 10.1038/cr.2011.188; published online 22 November 2011

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