Volume 21, No 3, Mar 2011
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 21 Issue 3, March 2011: 375-380
COMMENTARY
Lysine methylation of promoter-bound transcription factors and relevance to cancer
George R Stark1,2, Yuxin Wang1,2 and Tao Lu1
1Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
2Institute of Cancer Biology and Drug Screening, School of Life Science, Lanzhou University, Lanzhou 730000, China
Correspondence: George R Stark,(starkg@ccf.org)
p53, NFκB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones. The methylations of NF?B and STAT3 take place when they are bound to promoters, suggesting a more general model in which the binding of inducible transcription factors to DNA helps to recruit chromatin-modification machinery, which then may modify not only histones but also the bound transcription factors. Mutations of some histone-lysine methyltransferases and demethylases are linked to cancer, and these mutations may alter the methylation not only of histones but also of transcription factors, and thus may be tumorigenic through more than one mechanism.
Cell Research (2011) 21:375-380. doi:10.1038/cr.2010.174; published online 14 December 2010
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