Volume 21, No 3, Mar 2011

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 21 Issue 3, March 2011: 381-395

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Regulation of chromatin by histone modifications

Andrew J Bannister and Tony Kouzarides

The Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge CB2 1QN, UK Correspondence: Tony Kouzarides,(t.kouzarides@gurdon.cam.ac.uk)

Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to external cues to regulate the many uses of DNA. A principle component of chromatin that plays a key role in this regulation is the modification of histones. There is an ever-growing list of these modifications and the complexity of their action is only just beginning to be understood. However, it is clear that histone modifications play fundamental roles in most biological processes that are involved in the manipulation and expression of DNA. Here, we describe the known histone modifications, define where they are found genomically and discuss some of their functional consequences, concentrating mostly on transcription where the majority of characterisation has taken place.

Cell Research (2011) 21:381-395. doi:10.1038/cr.2011.22; published online 15 February 2011

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