Volume 21, No 2, Feb 2011

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 21 Issue 2, February 2011: 223-244

REVIEWS

NF-κB in immunobiology

Matthew S Hayden and Sankar Ghosh

Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Correspondence: Sankar Ghosh,(sg2715@columbia.edu)

NF-κB was first discovered and characterized 25 years ago as a key regulator of inducible gene expression in the immune system. Thus, it is not surprising that the clearest biological role of NF-κB is in the development and function of the immune system. Both innate and adaptive immune responses as well as the development and maintenance of the cells and tissues that comprise the immune system are, at multiple steps, under the control of the NF-κB family of transcription factors. Although this is a well-studied area of NF-κB research, new and significant findings continue to accumulate. This review will focus on these areas of recent progress while also providing a broad overview of the roles of NF-κB in mammalian immunobiology.

Cell Research (2011) 21: 223-244. doi:10.1038/cr.2011.13; published online 18 January 2011

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