Volume 21, No 1, Jan 2011

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 21 Issue 1, January 2011: 103-115

REVIEWS

Crosstalk of reactive oxygen species and NF-κB signaling

Michael J Morgan and Zheng-gang Liu

Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, RM1130, Bethesda, MD 20892 Correspondence: Zheng-gang Liu,(zgliu@helix.nih.gov)

NF-κB proteins are a family of transcription factors that are of central importance in inflammation and immunity. NF-κB also plays important roles in other processes, including development, cell growth and survival, and proliferation, and is involved in many pathological conditions. Reactive Oxygen Species (ROS) are created by a variety of cellular processes as part of cellular signaling events. While certain NF-κB-regulated genes play a major role in regulating the amount of ROS in the cell, ROS have various inhibitory or stimulatory roles in NF-κB signaling. Here we review the regulation of ROS levels by NF-κB targets and various ways in which ROS have been proposed to impact NF-κB signaling pathways.

Cell Research (2011) 21:103-115. doi:10.1038/cr.2010.178; published online 28 December 2010

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