Volume 21, No 1, Jan 2011

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 21 Issue 1, January 2011: 169-182

REVIEWS

Role of NF-κB in the skeleton

Deborah Veis Novack

Division of Bone and Mineral Diseases, Departments of Medicine and Pathology, Washington University School of Medicine, St Louis, MO, USA Correspondence: Deborah Veis Novack(novack@wustl.edu)

Since the discovery that deletion of the NF-κB subunits p50 and p52 causes osteopetrosis in mice, there has been considerable interest in the role of NF-κB signaling in bone. NF-κB controls the differentiation or activity of the major skeletal cell types ?osteoclasts, osteoblasts, osteocytes and chondrocytes. However, with five NF-κB subunits and two distinct activation pathways, not all NF-κB signals lead to the same physiologic responses. In this review, we will describe the roles of various NF-κB proteins in basal bone homeostasis and disease states, and explore how NF-κB inhibition might be utilized therapeutically.

Cell Research (2011) 21:169-182. doi:10.1038/cr.2010.159; published online 16 November 2010

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