Volume 21, No 1, Jan 2011

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 21 Issue 1, January 2011: 183-195

REVIEWS

Structural studies of NF-κB signaling

Chao Zheng*, Qian Yin* and Hao Wu

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10021, USA Correspondence: Hao Wu,(haowu@med.cornell.edu)

NF-κBs are a family of transcription factors that control a number of essential cellular functions including immune responses, cell proliferation and antiapoptosis. NF-κB activities are tightly regulated through upstream signaling molecules and downstream feedback loops. In this review, structural discoveries in the NF-κB pathway are presented. With the structure information, the following questions may be addressed: (1) How do NF-κBs activate their target genes? (2) How do IκBs inhibit NF-κB activities in the steady state? (3) How do upstream signaling molecules activate the NF-κB pathway? and (4) How do the feedback loops shut down the NF-κB pathway to avoid constitutive NF-κB activation?

Cell Research (2011) 21:183-195. doi:10.1038/cr.2010.171; published online 7 December 2010

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