Volume 20, No 11, Nov 2010
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 20 Issue 11, November 2010: 1185-1187
COMMENTARY
Towards a cure for HIV: the identification and characterization of HIV reservoirs in optimally treated people
Adewunmi Onafuwa-Nuga1, Lucy A McNamara2,3 and Kathleen L Collins1,2
1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
2Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
3Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA
Correspondence: Kathleen L Collins,(klcollin@umich.edu)
Currently available anti-HIV-1 drugs suppress viral replication and maintain viral levels below the detection threshold of most assays but do not eliminate cellular reservoirs. As a result, very low levels of circulating virus can be detected in most people despite long-term treatment with potent anti-HIV drug combinations. Not surprisingly, viral levels rebound with discontinuation of treatment. New evidence indicates that there is a viral reservoir in bone marrow progenitor cells.
Cell Research (2010) 20:1185–1187. doi:10.1038/cr.2010.140; published online 28 September 2010
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