Volume 20, No 10, Oct 2010

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 20 Issue 10, October 2010: 1092-1095

COMMENTARY

iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability

Veronica Ramos-Mejia*, Martin Muñoz-Lopez*, Jose L Garcia-Perez and Pablo Menendez

Andalusian Stem Cell Bank, Centro de Investigacion Biomedica, CSJA-UGR, Granada, Spain Correspondence: Pablo Menendez, Jose L García-Perez,(pablo.menendez@juntadeandalucia.es; josel.garcía.perez@juntadeandalucia.es)

Here, we provide data suggesting that the absence of silencing of the ectopic reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells (iPSCs) may predispose iPSCs to genomic instability. We encourage stem cell scientists to undertake an extensive characterization and standardization of much larger cohorts of iPSC lines in order to set up rigorous criteria to define safe and stable bona fide iPSCs.

Cell Research (2010) 20:1092–1095. doi:10.1038/cr.2010.125; published online 7 September 2010

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