Volume 20, No 10, Oct 2010

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 20 Issue 10, October 2010: 1158-1169

ORIGINAL ARTICLES

miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β

Wei Sun, Wenwen Shen, Shuang Yang, Fen Hu, Huihui Li and Tian-Hui Zhu

Laboratory of Molecular Genetics, College of Medicine, Nankai University, Tianjin 300071, China Correspondence: Tian-Hui Zhu,(zhuth@nankai.edu.cn)

miR-142 and miR-223 have been identified as hematopoietic specific microRNAs. miR-223 has crucial functions in myeloid lineage development. However, the function of miR-142 remains unclear. In this study, we found that both miR-142 and miR-223 attenuated the proliferation of hematopoietic cells, and that miR-223 up-regulated miR-142 expression through the LMO2-L/-S isoforms and CEBP-β. miR-223 negatively regulated both LMO2-L/-S isoforms and CEBP-β post-transcriptionally, while CEBP-β positively regulated the LMO2-L/-S isoforms and both of the LMO2-L/-S isoforms negatively regulated miR-142. These results reveal a novel miR-223-CEBP-β-LMO2-miR-142 regulatory pathway, which has pivotal functions in hematopoiesis.

Cell Research (2010) 20:1158–1169. doi:10.1038/cr.2010.134; published online 21 September 2010

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