Volume 20, No 1, Jan 2010
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 20 Issue 1, January 2010: 13-23
REVIEWS
Quick to remember, slow to forget: rapid recall responses of memory CD8+ T cells
Joanna R DiSpirito1 and Hao Shen1,2
1Department of Microbiology, University of Pennsylvania School of Medicine Philadelphia, PA 19104, USA
2Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China
Correspondence: Hao Shen,(hshen@mail.med.upenn.edu)
The complement system plays a crucial role in the innate defense against common pathogens. Activation of complement leads to robust and efficient proteolytic cascades, which terminate in opsonization and lysis of the pathogen as well as in the generation of the classical inflammatory response through the production of potent proinflammatory molecules. More recently, however, the role of complement in the immune response has been expanded due to observations that link complement activation to adaptive immune responses. It is now appreciated that complement is a functional bridge between innate and adaptive immune responses that allows an integrated host defense to pathogenic challenges. As such, a study of its functions allows insight into the molecular underpinnings of host-pathogen interactions as well as the organization and orchestration of the host immune response. This review attempts to summarize the roles that complement plays in both innate and adaptive immune responses and the consequences of these interactions on host defense.
Cell Research (2010) 20:13-23. doi: 10.1038/cr.2009.140; published online 22 December 2009
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