Volume 19, No 7, Jul 2009
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 19 Issue 7, July 2009: 802-815
REVIEWS
Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis
Jianxin Lu1, Lokendra Kumar Sharma2 and Yidong Bai1,2
1Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical College, Wenzhou 325035, China
2Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Correspondence: Yidong Bai,(baiy@uthscsa.edu)
Alterations in oxidative phosphorylation resulting from mitochondrial dysfunction have long been hypothesized to be involved in tumorigenesis. Mitochondria have recently been shown to play an important role in regulating both programmed cell death and cell proliferation. Furthermore, mitochondrial DNA (mtDNA) mutations have been found in various cancer cells. However, the role of these mtDNA mutations in tumorigenesis remains largely unknown. This review focuses on basic mitochondrial genetics, mtDNA mutations and consequential mitochondrial dysfunction associated with cancer. The potential molecular mechanisms, mediating the pathogenesis from mtDNA mutations and mitochondrial dysfunction to tumorigenesis are also discussed.
Cell Research (2009) 19:802-815. doi: 10.1038/cr.2009.69; published online 16 June 2009
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