Volume 19, No 5, May 2009
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 19 Issue 5, May 2009: 532-545
REVIEWS
Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis
Shih-Lei Lai1,2, Andy J Chien1 and Randall T Moon1
1Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
2Institute of Zoology, National Taiwan University, Taipei 10617
Correspondence: Randall T Moon,(Randall T Moon,)
Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. β-Catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both β-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.
Cell Research (2009) 19:532-545. doi: 10.1038/cr.2009.41; published online 14 April 2009
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