Volume 19, No 1, Jan 2009

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 19 Issue 1, January 2009: 21-35

REVIEWS

Regulating the stability of TGFβ receptors and Smads

Peter Lönn, Anita Morén, Erna Raja, Markus Dahl and Aristidis Moustakas

Ludwig Institute for Cancer Research, Uppsala University, Box 595, Biomedical Center, SE-751 24 Uppsala, Sweden Correspondence: Aristidis Moustakas,(aris.moustakas@licr.uu.se)

Transforming growth factor β (TGFβ) controls cellular behavior in embryonic and adult tissues. TGFβ binding to serine/threonine kinase receptors on the plasma membrane activates Smad molecules and additional signaling proteins that together regulate gene expression. In this review, mechanisms and models that aim at explaining the coordination between several components of the signaling network downstream of TGFβ are presented. We discuss how the activity and duration of TGFβ receptor/Smad signaling can be regulated by post-translational modifications that affect the stability of key proteins in the pathway. We highlight links between these mechanisms and human diseases, such as tissue fibrosis and cancer.

Cell Research (2009) 19:21-35. doi: 10.1038/cr.2008.308; published online 25 November 2008

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