Volume 19, No 1, Jan 2009

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 19 Issue 1, January 2009: 47-57

REVIEWS

Ski and SnoN, potent negative regulators of TGF-β signaling

Julien Deheuninck and Kunxin Luo

UC Berkeley, Department of Molecular and Cellular Biology, 16 Barker Hall, MC3204, Berkeley, CA 94720, USA Correspondence: Kunxin Luo,

Ski and the closely related SnoN were discovered as oncogenes by their ability to transform chicken embryo fibroblasts upon overexpression. While elevated expressions of Ski and SnoN have also been reported in many human cancer cells and tissues, consistent with their pro-oncogenic activity, emerging evidence also suggests a potential anti-oncogenic activity for both. In addition, Ski and SnoN have been implicated in regulation of cell differentiation, especially in the muscle and neuronal lineages. Multiple cellular partners of Ski and SnoN have been identified in an effort to understand the molecular mechanisms underlying the complex roles of Ski and SnoN. In this review, we summarize recent findings on the biological functions of Ski and SnoN, their mechanisms of action and how their levels of expression are regulated.

Cell Research (2009) 19:47-57. doi: 10.1038/cr.2008.324; published online 30 December 2008

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