Volume 19, No 1, Jan 2009

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 19 Issue 1, January 2009: 71-88

REVIEWS

Signaling cross-talk between TGF-β/BMP and other pathways

Xing Guo* and Xiao-Fan Wang

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
*Current address: Department of Pharmacology, University of California,
San Diego, La Jolla, CA 92093, USA Correspondence: Xiao-Fan Wang,(wang0011@mc.duke.edu)

Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of all metazoans. Deregulation of TGF-β/BMP activity almost invariably leads to developmental defects and/or diseases, including cancer. The proper functioning of the TGF-β/BMP pathway depends on its constitutive and extensive communication with other signaling pathways, leading to synergistic or antagonistic effects and eventually desirable biological outcomes. The nature of such signaling cross-talk is overwhelmingly complex and highly context-dependent. Here we review the different modes of cross-talk between TGF-β/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/Akt, Wnt, Hedgehog, Notch, and the interleukin/interferon-gamma/tumor necrosis factor-alpha cytokines, with an emphasis on the underlying molecular mechanisms.

Cell Research (2009) 19:71-88. doi: 10.1038/cr.2008.302; published online 11 November 2008

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