Volume 18, No 8, Aug 2008
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 18 Issue 8, August 2008: 823-833
ORIGINAL ARTICLES
Overlapping expression of microRNAs in human embryonic colon and colorectal cancer
Mariano Monzo1,4,*, Alfons Navarro1,4,*, Eva Bandres2, Rosa Artells1,4, Isabel Moreno3, Bernat Gel1, Rafael Ibeas3, Jose Moreno3, Francisco Martinez3, Tania Diaz1, Antonio Martinez4,5, Olga Balagué4,5 and Jesus Garcia-Foncillas2
1Department of Human Anatomy and Embryology, School of Medicine, University of Barcelona, Barcelona, Spain;
2Laboratory of Pharmacogenomics, Center for Applied Medical Research, University of Navarra, Spain;
3Department of Medical Oncology and Surgery, Hospital Municipal de Badalona, Badalona, Spain;
4Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), School of Medicine, University of Barcelona, Barcelona, Spain;
5Hematopathology Section, Laboratory of Pathology, Hospital Clinic, Barcelona, Spain
Correspondence: Mariano Monzo(mmonzo@ub.edu)
MicroRNAs (miRNAs) are essential for regulating cell differentiation and maintaining the pluripotent state of stem cells. Although dysregulation of specific miRNAs has been associated with certain types of cancer, to date no evidence has linked miRNA expression in embryonic and tumor tissues. We assessed the expression of mature miRNAs in human embryonic colon tissue, and in colorectal cancer and paired normal colon tissue. Overlapping miRNA expression was detected between embryonic colonic mucosa and colorectal cancer. We have found that the miR-17-92 cluster and its target, E2F1, exhibit a similar pattern of expression in human colon development and colonic carcinogenesis, regulating cell proliferation in both cases. In situ hybridization confirmed the high level of expression of miR-17-5p in the crypt progenitor compartment. We conclude that miRNA pathways play a major role in both embryonic development and neoplastic transformation of the colonic epithelium.
Cell Research (2008) 18:823-833. doi: 10.1038/cr.2008.81; published online 8 July 2008
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