Volume 18, No 7, Jul 2008

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 18 Issue 7, July 2008: 716-724

REVIEWS

Mapping the human protein interactome

Daniel Figeys

The Ottawa Institute of Systems Biology, The Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canad Correspondence: Daniel Figeys(dfigeys@uottawa.ca)

Interactions are the essence of all biomolecules because they cannot fulfill their roles without interacting with other molecules. Hence, mapping the interactions of biomolecules can be useful for understanding their roles and functions. Furthermore, the development of molecular based systems biology requires an understanding of the biomolecular interactions. In recent years, the mapping of protein-protein interactions in different species has been reported, but few reports have focused on the large-scale mapping of protein-protein interactions in human. Here, we review the developments in protein interaction mapping and we discuss issues and strategies for the mapping of the human protein interactome.

Cell Research (2008) 18:716-724. doi: 10.1038/cr.2008.72; published online 24 June 2008

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