Volume 18, No 4, Apr 2008

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 18 Issue 4, April 2008: 443-451

REVIEWS

Roles of unphosphorylated STATs in signaling

Jinbo Yang^1,2 and George R Stark²

¹School of Biological Science, Lanzhou University, Lanzhou, Gansu 730000, China
²Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH 44195, USA Correspondence: George R Stark Jinbo Yang,(starkg@ccf.org; yangj@ccf.org )

The seven members of the signal transducer and activator of transcription (STAT) family of transcription factors are activated in response to many different cytokines and growth factors by phosphorylation of specific tyrosine residues. The STAT1 and STAT3 genes are specific targets of activated STATs 1 and 3, respectively, resulting in large increases in the levels of these unphosphorylated STATs (U-STATs) in response to the interferons (STAT1) or ligands that active gp130, such as IL-6 (STAT3). U-STATs drive gene expression by novel mechanisms distinct from those used by phosphorylated STAT (P-STAT) dimers. In this review, we discuss the roles of U-STATs in transcription and regulation of gene expression.

Cell Research (2008) 18:443-451. doi: 10.1038/cr.2008.41: published online 25 March 2008

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