Volume 18, No 2, Feb 2008

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 18 Issue 2, February 2008: 254-267

REVIEWS

STAT3 as a target for inducing apoptosis in solid and hematological tumors

Khandaker Al Zaid Siddiquee and James Turkson

Biomolecular Science Center and Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, FL 32826, USA Correspondence: James Turkson(jturkson@mail.ucf.edu )

Studies in the past few years have provided compelling evidence for the critical role of aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant transformation and tumorigenesis. Thus, it is now generally accepted that STAT3 is one of the critical players in human cancer formation and represents a valid target for novel anticancer drug design. This review focuses on aberrant STAT3 and its role in promoting tumor cell survival and supporting the malignant phenotype. A brief evaluation of the current strategies targeting STAT3 for the development of novel anticancer agents against human tumors harboring constitutively active STAT3 will also be presented.

Cell Research (2008) 18:254-267. doi: 10.1038/cr.2008.18; published online 29 January 2008

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