Volume 17, No 7, Jul 2007

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 17 Issue 7, July 2007: 581-590

REVIEWS

Systems perspectives on mRNA processing

Adrienne E McKee and Pamela A Silver

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA Correspondence: Pamela A Silver(pamela_silver@hms.harvard.edu)

The application of genomic technologies to the study of mRNA processing is increasingly conducted in metazoan organisms in order to understand the complex events that occur during and after transcription. Large-scale systems analyses of mRNA-protein interactions and mRNA dynamics have revealed specificity in mRNA transcription, splicing, transport, translation, and turnover, and have begun to make connections between the different layers of mRNA processing. Here, we review global studies of post-transcriptional processes and discuss the challenges facing our understanding of mRNA regulation in metazoan organisms. In parallel, we examine genome-scale investigations that have expanded our knowledge of RNA-binding proteins and the networks of mRNAs that they regulate.

Cell Research (2007) 17:581-590. doi: 10.1038/cr.2007.54; published online 10 July 2007

FULL TEXT | PDF

Browse 1591