Volume 17, No 3, Mar 2007

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 17 Issue 3, March 2007: 187-194

REVIEWS

Biochemical mechanisms of the RNA-induced silencing complex

Zain Paroo¹, Qinghua Liu¹, Xiaodong Wang^1,2

¹Department of Biochemistry, ²Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry
Hines Blvd, Dallas, TX 75390, USA Correspondence: Qinghua Liu Xiaodong Wang(qinghua.liu@UTSouthwestern.edu xiaodong.wang@UTSouthwestern.edu)

In less than 10 years since its inception, RNA interference (RNAi) has had extraordinary impact on biomedical science. RNAi has been demonstrated to influence numerous biological and disease pathways. Development and adoption of RNAi technologies have been prolific ranging from basic loss-of-function tools, genome-wide screening libraries to pharmaceutical target validation and therapeutic development. However, understanding of the molecular mechanisms of RNAi is far from complete. The purpose of this brief review is to highlight key achievements in elucidating the biochemical mechanisms of the RNA-induced silencing complex and to outline major challenges for the field.

Cell Research (2007) 17: 187-194. doi: 10.1038/sj.cr.7310148; published online 20 February 2007

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