Volume 17, No 2, Feb 2007
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 17 Issue 2, February 2007: 89-99
REVIEWS
Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy
Qi Zhang1, Guihua Chen1, Xinyuan Liu2, Qijun Qian3
1Transplantation Research Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe
Rd, Guangzhou 510630, China; 2Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China;
3Laboratory of Viral and Gene Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai
Rd, Shanghai 200438, China
Correspondence: Qijun Qian(qianqj@sino-gene.cn)
Antibodies as therapeutic agents are mostly used in oncology, as illustrated by their applications in lymphoma, breast cancer or colorectal cancer. This review provides a brief historical sketch of the development of monoclonal antibodies for cancer treatment and summarizes the most significant clinical data for the best-established reagents to date. It also discusses strategies to improve the anti-tumor efficacy of antibody therapy, including antibody gene therapy and exploitation of bone marrow derived primary mesenchymal stem cells as the antibody gene transporter.
Cell Research (2007) 17:89-99. doi: 10.1038/sj.cr.7310143; published online 23 January 2007
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