Volume 17, No 1, Jan 2007
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 17 Issue 1, January 2007: 50-55
REVIEWS
Thymic epithelial progenitor cells and thymus regeneration: an update
Lianjun Zhang1,2, Liguang Sun1,3, Yong Zhao1
1Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology,
2Graduate University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100080, China; 3School of
Public Health, Jilin University, Changchun 130021, China
Correspondence: Yong Zhao(zhaoy@ioz.ac.cn)
The thymus provides the essential microenvironment for T-cell development and maturation. Thymic epithelial cells (TECs), which are composed of thymic cortical epithelial cells (cTECs) and thymic medullary epithelial cells (mTECs), have been well documented to be critical for these tightly regulated processes. It has long been controversial whether the common progenitor cells of TECs could give rise to both cTECs and mTECs. Great progress has been made to characterize the common TEC progenitor cells in recent years. We herein discuss the sole origin paradigm with regard to TEC differentiation as well as these progenitor cells in thymus regeneration.
Cell Research (2007) 17:50-55. doi:10.1038/sj.cr.7310114; published online 5 December 2007
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