Volume 16, No 11, Nov 2006
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 16 Issue 11, November 2006: 902-907
ORIGINAL ARTICLES
Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes
Yeonseok Chung, Xuexian Yang, Seon Hee Chang, Li Ma, Qiang Tian, Chen Dong
1Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA; 2Institute for Systems Biology, Seattle, WA 98103, USA
Correspondence: Chen Dong(cdong@mdanderson.org)
IL-22 is a novel cytokine in the IL-10 family that functions to promote innate immunity of tissues against infection. Although CD4+ helper T lymphocytes (TH) were found as a source of IL-22, the regulation of this cytokine has been poorly understood. Here, we show that IL-22 is expressed at both mRNA and protein levels by a novel subset of TH cells that also makes IL-17. IL-22 and IL-17 were found to be coordinately regulated by TGFb and IL-6 during TH differentiation by real-time PCR as well as ELISA analysis. However, IL-22 does not regulate TH differentiation; exogenous IL-22 or an IL-22 antagonist had no effect on TH differentiation. These data demonstrate a novel cytokine expressed by IL-17-producing T cells, and suggest interaction and synergy of IL-22 and IL-17 signaling pathways in tissue inflammation and autoimmune diseases.
Cell Research (2006) 16:902-907. doi:10.1038/sj.cr.7310106; published online 7 November 2006
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