Volume 16, No 8, Aug 2006

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 16 Issue 8, August 2006: 713-722

ORIGINAL ARTICLES

Skeletal myogenesis by human embryonic stem cells

Jun Ke Zheng, Yi Wang, Aditi Karandikar, Qian Wang, Hui Gai, Ai Lian Liu, Chao Peng, Hui Zhen Sheng,

¹Center for Developmental Biology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kong Jiang Road, Shanghai 200092, China; ²Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China Correspondence: Hui Zhen Sheng(hzsheng2003@yahoo.com)

We have examined the myogenic potential of human embryonic stem (hES) cells in a xeno-transplantation animal model. Here we show that precursors differentiated from hES cells can undergo myogenesis in an adult environment and give rise to a range of cell types in the myogenic lineage. This study provides direct evidences that hES cells can regenerate both muscle and satellite cells in vivo and are another promising cell type for treating muscle degenerative disorders in addition to other myogenic cell types.

Cell Research (2006) 16:713-722. doi:10.1038/sj.cr.7310080; published online 20 June 2006

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