Volume 16, No 7, Jul 2006
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 16 Issue 7, July 2006: 671-677
ORIGINAL ARTICLES
Glycogen synthase kinase-3β positively regulates the proliferation of human ovarian cancer cells
Qi Cao, Xin Lu, You-Ji Feng
1Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
Correspondence: You-Ji Feng(fengyj4806@sohu.com )
Although glycogen synthase kinase-3 (GSK-3) might act as a tumor suppressor since its inhibition is expected to
mimic the activation of Wnt-signaling pathway, GSK-3β may contribute to NF-?B activation in cancer cells leading to
increased cancer cell proliferation and survival. Here we report that GSK-3β activity was involved in the proliferation
of human ovarian cancer cell both in vitro and in vivo. Inhibition of GSK-3 activity by pharmacological inhibitors suppressed
proliferation of the ovarian cancer cells. Overexpressing constitutively active form of GSK-3β induced entry
into the S phase, increased cyclin D1 expression and facilitated the proliferation of ovarian cancer cells. Furthermore,
GSK-3 inhibition prevented the formation of the tumor in nude mice generated by the inoculation of human ovarian
cancer cells. Our findings thus suggest that GSK-3β activity is important for the proliferation of ovarian cancer cells,
implicating this kinase as a potential therapeutic target in ovarian cancer.
Cell Research advance online publication 20 Jun 2006; doi: 10.1038/sj.cr.7310078
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