Volume 16, No 6, Jun 2006
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 16 Issue 6, June 2006: 559-565
ORIGINAL ARTICLES
MEF2C mediates the activation induced cell death (AICD) of macrophages
Wenxia Fu, Jinxue Wei, Jun Gu
1National Key Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Science, Peking University, Beijing 100871, China
Correspondence: Jun Gu(gj@pku.edu.cn)
Activation-induced cell death (AICD) of immune cells is widely believed to be crucial for the regulation of immune
responses. Although macrophage apoptosis has been observed under a variety of pathological conditions, questions as to
whether there is AICD of macrophages and how macrophage life span is regulated have not been well addressed. AICD
in macrophages requires two signals. One is cell activation triggered by LPS or other bacterial components. The other
is an event that exists in AICD-susceptible (primed) but not unsusceptible (resting) macrophages. Here we show that
RAW264.7 cell is susceptible to LPS stimulation when it is primed with Salmonella typhimurium, type 5 adenovirus
(Ad5) or
IFN-γ. We found that the stability of the transcription factor MEF2C is increased in primed RAW264.7 cell.
Transfection of a dominant negative form of MEF2C protects primed macrophage from cell death triggered by LPS. Our
data demonstrate that the increase of MEF2C protein stability is a key factor in the AICD of macrophage.
Cell Research (2006) 16:559-565. doi:10.1038/sj.cr.7310073; published online 15 June 2006
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