Volume 16, No 3, Mar 2006
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 16 Issue 3, March 2006: 323-327
LETTERS TO THE EDITOR
Evolutionary implications of Avian Infectious Bronchitis Virus (AIBV)analysis
Peng Shi1, 2, *, Li Yu2, *, Yun-xin Fu3, Jing-Fei Huang1, Ke-Qin Zhang2, Ya-ping Zhang1, 2
1Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese
Academy of Sciences, Kunming 650223, China; 2Laboratory for Conservation and Utilization of Bio-resource, Yunnan University,
Kunming 650091, China; 3Human Genetics Center, University of Texas at Houston, Houston, Texas 77030, USA
Correspondence: Ya-ping Zhang(zhangyp1@263.net.cn )
For developing efficient vaccines, it is essential to identify which amino acid changes are most important to the survival of the virus. We investigate the amino acid substitution features in the Avian Infectious Bronchitis Virus (AIBV) antigenic domain of a vaccine serotype (DE072) and a virulent viral strain (GA98) to better understand adaptive evolution of AIBV. In addition, the SARS Coronavirus (SARS-CoV) was also analyzed in the same way. It is interesting to find that extreme comparability exists between AIBV and SARS in amino acid substitution pattern. It suggests that amino acid changes that result in overall shift of residue charge and polarity should be paid special attention to during the development of vaccines.
Cell Research (2006) 16:323-327. doi:10.1038/sj.cr.7310041; published online 16 March 2006
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