Volume 16, No 2, Feb 2006

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 16 Issue 2, February 2006: 196-202

REVIEWS

Regulation of cytokine signaling pathways by PIAS proteins

Ke Shuai

Division of Hematology-Oncology, Department of Medicine; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California 90095, USA Correspondence: Ke Shuai(kshuai@mednet.ucla.edu)

Cytokines activate multiple signal transduction pathways to regulate gene expression. STATs and NF-kB are two important families of transcription factors activated by cytokines. Abnormal regulation of STAT and NF-kB activities has been associated with human diseases. The protein inhibitor of activated STAT (PIAS) protein family has been proposed to interact with over 60 proteins, many of which are transcription factors involved in the immune system. PIAS proteins regulate transcription through several mechanisms, including blocking the DNA-binding activity of transcription factors, recruiting transcriptional co-repressors and promoting protein sumoylation. This article is to review the role of PIAS proteins in the regulation of STAT and NF-kB signaling pathways.

Cell Research (2006) 16:196-202. doi:10.1038/sj.cr.7310027; published online 13 February 2006

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