Advanced Search
Submit Manuscript Advanced Search
Submit Manuscript
Volume 15, No 10, Oct 2005
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 15 Issue 10, October 2005: 777-784
Mi Dan AI1, Li Li LI1, Xiao Rong ZHAO1, Yong WU1, Jian Ping GONG2, Ya CAO1,*
1Cancer Research Institute, Xiangya School of Medicine, Central South University, 110 Xiangya Road, Changsha, HunanReceived, Sep 12, 2005; Revised, Sep 26, 2005; Accepted, Oct 15,2005
Correspondence: Ya CAO(E-mail:ycao98@public.cs.hn.cn)
Latent membrane protein 1 (LMP1), an important protein encoded by Epstein Barr virus (EBV), has been implied to link with the pathogenesis of nasopharyngeal carcinoma (NPC). Its dual effects of increasing cell proliferation and inhibiting cell apoptosis have been confirmed. In this study, we showed that the expression of Survivin and CDK4 protein in CNE-LMP1, a LMP1 positive NPC epithelial cell line, is higher than in LMP1 negative NPC epithelial cell line-CNE1, and the expression is LMP1 dosage-dependent. Although it was reported that Survivin specifically expressed in cell cycle G2/M phase, our studies suggested that LMP1 could promote the expression of Survivin in G0/G1, S and G2/M phase. It also showed that Survivin and CDK4 could be accumulated more in the nuclei triggered by LMP1. More interestingly, Survivin and CDK4 could form a protein complex in the nuclei of CNE-LMP1 rather than in that of CNE1, which demonstrated that the interaction between these two proteins could be promoted by LMP1. These results strongly suggested that the role of LMP1 in the regulation of Survivin and CDK4 may also shed some light on the mechanism research of LMP1 in NPC.
