Volume 15, No 6, Jun 2005
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 15 Issue 6, June 2005: 407-422
REVIEWS
The host type I interferon response to viral and bacterial infections
Andrea K. Perry1*, Gang Chen2,*, Dahai Zheng2,*, Hong Tang2, Genhong Cheng1,2,**
1 Department of Microbiology, Immunology and Molecular Genetics,
University of California Los Angeles, Los Angeles, CA 90095, USA;
2Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Correspondence: G. Cheng(genhongc@microbio.ucla.edu)
Type I interferons (IFN) are well studied cytokines with anti-viral and immune-modulating functions. Type I IFNs are produced following viral infections, but until recently, the mechanisms of viral recognition leading to IFN production were largely unknown. Toll like receptors (TLRs) have emerged as key transducers of type I IFN during viral infections by recognizing various viral components. Furthermore, much progress has been made in defining the signaling pathways downstream of TLRs for type I IFN production. TLR7 and TLR9 have become apparent as universally important in inducing type I IFN during infection with most viruses, particularly by plasmacytoid dendritic cells. New intracellular viral pattern recognition receptors leading to type I IFN production have been identified. Many bacteria can also induce the up-regulation of these cytokines. Interestingly, recent studies have found a detrimental effect on host cells if type I IFN is produced during infection with the intracellular gram-positive bacterial pathogen, Listeria monocytogenes. This review will discuss the recent advances made in defining the signaling pathways leading to type I IFN production.
FULL TEXT | PDF
Browse 1907
