Volume 15, No 5, May 2005
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 15 Issue 5, May 2005: 301-316
REVIEWS
Making a tooth: growth factors, transcription factors, and stem cells
Yan Ding ZHANG1,2, Zhi CHEN1, Yi Qiang SONG3, Chao LIU2, Yi Ping CHEN2,3,*
1College of Stomatology, Wuhan University, Wuhan 430072, China
2College of Bioengineering, Fujian Normal University, Fuzhou 350007, China
3Division of Developmental Biology, Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
Correspondence: Yi Ping CHEN(ychen@tulane.edu)
Mammalian tooth development is largely dependent on sequential and reciprocal epithelial-mesenchymal interactions. These processes involve a series of inductive and permissive interactions that result in the determination, differentiation, and organization of odontogenic tissues. Multiple signaling molecules, including BMPs, FGFs, Shh, and Wnt proteins, have been implicated in mediating these tissue interactions. Transcription factors participate in epithelial-mesenchymal interactions via linking the signaling loops between tissue layers by responding to inductive signals and regulating the expression of other signaling molecules. Adult stem cells are highly plastic and multipotent. These cells including dental pulp stem cells and bone marrow stromal cells could be reprogrammed into odontogenic fate and participated in tooth formation. Recent progress in the studies of molecular basis of tooth development, adult stem cell biology, and regeneration will provide fundamental knowledge for the realization of human tooth regeneration in the near future.
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