Volume 15, No 3, Mar 2005

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 15 Issue 3, March 2005: 160-166

ORIGINAL ARTICLES

Overexpression of Bax sensitizes prostate cancer cells to TGF-β induced apoptosis

Pei Hui LIN¹, Zui PAN¹, Lin ZHENG¹, Na LI¹, David DANIELPOUR², Jian Jie MA^1,*

¹Department of Physiology and Biophysics, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
²Ireland Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA Correspondence: Jian Jie MA(maj2@umdnj.edu)

NRP-154 is a tumorigenic epithelial cell line derived from the preneoplastic dorsal-lateral prostate of rats. These cells are exquisitely sensitive to TGF-β induced apoptosis. In contrast, we find that NRP-154 cells can sustain overexpression of exogenous Bax protein, which is different from non-tumor cells where Bax functions as a ubiquitous stimulator of apoptosis. NRP-154 cells stably overexpressing Bax show increased sensitivity to TGF-β induced apoptosis. The degree of TGF-β induced apoptosis displays high correlation with cleavage of Bax at the amino-terminus. Our data indicate that prostate cancer cells can host high levels of latent Bax which can be activated through post-translational modification.

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