Volume 15, No 2, Feb 2005

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 15 Issue 2, February 2005: 83-91

REVIEWS

Inositol 1,4,5-trisphosphate 3-kinases: functions and regulations

Hui Jun XIA*, Guang YANG

Key Laboratory of MOE for Plant Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China Correspondence: Hui Jun XIA(hjxia@whu.edu.cn)

Inositol 1,4,5-trisphosphate 3-kinase (IP₃ 3-kinase/IP3K)
plays an important role in signal transduction in animal cells by phosphorylating
inositol 1,4,5-trisphosphate (IP₃) to inositol 1,3,4,5-tetrakisphosphate
(IP₄). Both IP₃ and IP₄ are critical
second messengers which regulate calcium (Ca²⁺) homeostasis.
Mammalian IP3Ks are involved in many biological processes, including brain
development, memory, learning and so on. It is widely reported that Ca²⁺
is a canonical second messenger in higher plants. Therefore, plant IP3K
should also play a crucial role in plant development. Recently, we reported
the identification of plant IP3K gene (AtIpk2β/AtIP3K) from Arabidopsis
thaliana and its characterization. Here, we summarize the molecular
cloning, biochemical properties and biological functions of IP3Ks from
animal, yeast and plant. This review also discusses potential functions
of IP3Ks in signaling crosstalk, inositol phosphate metabolism, gene transcriptional
control and so on.

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