Volume 15, No 1, Jan 2005

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 15 Issue 1, January 2005: 49-51

REVIEWS

HGF/SF-Met signaling in tumor progression

Chong Feng GAO, George F. VANDE WOUDE*

Laboratory of Molecular Oncology, Van Andel Research Institute,#333 Bostwick Ave., N.E, Grand Rapids, MI 49503, USA Correspondence: George F. VANDE WOUDE(george.vandewoude@vai.org)

Tumor progression is a multi-step process that requires a sequential selection of specific malignant phenotypes. Met activation may induce different phenotypes depending on tumor stage: inducing proliferation and angiogenesis in primary tumors, stimulating motility to form micrometastases, and regaining the proliferation phenotype to form overt metastases. To study how HGF/SF-induced proliferative phenotypes switch to the invasive phenotype is important for understanding the mechanism of tumor progression and will provide an attractive target for cancer intervention and therapy.

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