Volume 15, No 1, Jan 2005

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 15 Issue 1, January 2005: 57-62

REVIEWS

Mechanisms of cancer metastasis to the bone

Juan Juan YIN, Claire B. POLLOCK, Kathleen KELLY*

Cell and Cancer Biology Branch, NCI, NIH, Bethesda, MD 20892, USA Correspondence: Kathleen KELLY(kkelly@helix.nih.gov)

Some of the most common human cancers, including breast cancer, prostate cancer, and lung cancer, metastasize with avidity to bone. What is the basis for their preferential growth within the bone microenvironment? Bidirectional interactions between tumor cells and cells that make up bone result in a selective advantage for tumor growth and can lead to bone destruction or new bone matrix deposition. This review discusses our current understanding of the molecular components and mechanisms that are responsible for those interactions.

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