Volume 15, No 1, Jan 2005
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 15 Issue 1, January 2005: 72-77
REVIEWS
Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between
Natalia JURA1,2, Herbert ARCHER1,2, Dafna BAR-SAGI1,*
1Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA.
2Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY 11794-5222, USA.
Correspondence: Dafna BAR-SAGI(barsagi@pharm.sunysb.edu)
Pancreatic cancer is a challenging disease for patients, doctors and researchers who for decades have searched for a cure for this deadly malignancy. Although existing mouse models of pancreatic cancer have shed light on the mechanistic basis of the neoplastic conversion of the pancreas, their impact in terms of offering new diagnostics and therapeutic modalities remains limited. Chronic pancreatitis is an inflammatory disease of the pancreas that is associated with a gradual damage of the organ and an increased risk of developing neoplastic lesions. In this review, we propose that detailed studies of chronic inflammatory processes in the pancreas will provide insights into the evolution of pancreatic cancer. This information may prove useful in the design of effective therapeutic strategies to battle the disease.
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