Volume 14, No 6, Dec 2004

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 14 Issue 6, December 2004: 441-449

REVIEWS

Negative regulation of TGF-β signaling in development

Ye Guang CHEN An Ming MENG

Correspondence: Ye Guang CHEN An Ming MENG(ygchen@mail.tsinghua.edu.cn mengam@mail.tsinghua.edu.cn)

The TGF-β superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to regulate expression of their target genes. Despite of the relatively simple signal transduction pathway, many modulators have been found to contribute to a tight regulation of this pathway in a variety of mechanisms. This article reviews the negative regulation of TGF-β signaling with focus on its roles in vertebrate development.

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