Volume 14, No 6, Dec 2004

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 14 Issue 6, December 2004: 461-467

REVIEWS

RNAi, a new therapeutic strategy against viral infection

Fischer L. Tan, James Q. Yin*

Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China. Correspondence: James Q. Yin(jqwyin@sun5.ibp.ac.cn)

RNA interference (RNAi) is an adaptive defense mechanism triggered by double-stranded RNA (dsRNA). It is a powerful reverse genetic tool that has been widely employed to silence gene expression in mammalian and human cells. RNAi-based gene therapies, especially in viral diseases have become more and more interesting and promising. Recently, small interfering RNA (siRNA) can be used to protect host from viral infection, inhibit the expression of viral antigen and accessory genes, control the transcription and replication of viral genome, hinder the assembly of viral particles, and display influences in virus-host interactions. In this review, we attempt to present recent progresses of this breakthrough technology in the above fields and summarize the possibilities of siRNA-based drugs.

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