Volume 13, No 6, Dec 2003

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 13 Issue 6, December 2003: 503-507

COMMENTARY

Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates

Zeenia KAUL, Tomoko YAGUCHI, Sunil C KAUL, Takashi HIRANO, Renu WADHWA*, Kazunari TAIRA

National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 3058562, Japan. Correspondence: Renu WADHWA(renu-wadhwa@aist.go.jp )

Quantum dots are the nanoparticles that are recently emerging as an alternative to organic fluorescence probes in cell biology and biomedicine, and have several predictive advantages. These include their i) broad absorption spectra allowing visualization with single light source, ii) exceptional photo-stability allowing long term studies and iii) narrow and symmetrical emission spectrum that is controlled by their size and material composition. These unique properties allow simultaneous excitation of different size of quantum dots with a single excitation light source, their simultaneous resolution and visualization as different colors. At present there are only a few studies that have tested quantum dots in cellular imaging. We describe here the use of quantum dots in mortalin imaging of normal and cancer cells. Mortalin staining pattern with quantum dots in both normal and cancer cells mimicked those obtained with organic florescence probes and were considerably stable.

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