Volume 13, No 3, Jun 2003
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 13 Issue 3, June 2003: 187-194
ORIGINAL ARTICLES
Cells in G2/M phase increased in human nasopharyngeal carcinoma cell line by EBV-LMP1 through activation of NF-
Lin DENG, Jing YANG, Xiao Rong ZHAO, Xi Yun DENG, Liang ZENG, Huan Hua GU, Min TANG, Ya CAO*
Cancer Research Institute, Xiangya School of Medicine, Central South University, Xiangya Road 88, Changsha, Hunan 410078, China
Correspondence: Ya CAO(ycao98@public.cs.hn.cn)
Although previous studies showed that the principal oncoprotein
encoded by Epstein-Barr virus, latent membrane protein 1(LMP1), could
induce the nasopharyngeal carcinoma cells in G
2/M phase increased,
little is known about the target molecules and mechanisms. The present
study demonstrated that LMP1 could induce the accumulation of p53 protein
and upregulate its transactivity in a dose dependent manner, which resulted
in the decrease of the kinase activity of cdc2/cyclin B complex and inducing
arrest at G
2/M phase through the activation of NF-
k>B and AP-1 signaling pathways, and the effect of NF-k>B was more obvious than that of AP-1. This study provided some significant evidence
for further elucidating the molecular mechanisms that LMP1 had effects
on the surveillance mechanism of cell cycle and promoting the survival
of transformed cells and tumorigenesis.
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