Volume 13, No 2, Apr 2003

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 13 Issue 2, April 2003: 69-81

REVIEWS

Function and regulation of Aurora/Ipl1p kinase family in cell division

Yu Wen KE¹, Zhen DOU¹, Jie ZHANG¹, Xue Biao YAO^1,2,*

¹Laboratory for Cell Dynamics, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
²Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA Correspondence: Xue Biao YAO(yaoxb@ustc.edu.cn)

During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p family, a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis. This article highlights the function and regulation of Aurora/Ipl1p family in mitosis and provides potential links between aberrant regulation of Aurora/Ipl1p kinases and pathogenesis of human cancer.

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