Volume 12, No 5-6, Dec 2002

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 12 Issue 5-6, December 2002: 407-410

COMMENTARY

Identification and characterization of a new member of serpin family- HongrES1 in rat epididymis

Zhi Hong HU, Qiang LIU, Quan SHANG, Min ZHENG, Jun YANG, Yong Lian ZHANG*

State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 200031, China Correspondence: Yong Lian ZHANG(yonglz@sunm.shcnc.ac.cn )

A full length cDNA named HongrES1 was isolated and cloned by screening rat epididymis cDNA library using a mouse EST as a probe and 5'RACE followed. It contained 1590bp nucleotides and its predicted protein had 415 amino acid residues including a serpin (serine protease inhibitor) conserved domain. Tissue distribution pattern showed it was specifically expressed in adult rat epididymis; moreover, in situ hybridyzation indicated this gene was expressed in a limited region of the cauda epididymis near vas deference. Such kind of expression pattern sugested that HongrES1 had potential function in male reproduction.

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