Volume 12, No 3-4, Sep 2002

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 12 Issue 3-4, September 2002: 207-214

ORIGINAL ARTICLES

The distribution of cofilin and DNase I in vivo

Deepak CHHABRA*, Shisan BAO, Cristobal G dos REMEDIOS

Muscle Research Unit, Department of Anatomy and Histology, Department of Pathology, Institute for Biomedical Research, F13, University of Sydney, NSW 2006, Australia Correspondence:

Actin is the principal component of the cytoskeleton, a structure that can be disassembled and reassembled in a matter of seconds in vivo. The state of assembly of actin in vivo is primarily regulated by one or more actin binding proteins (ABPs). Typically, the actions of ABPs have been studied one by one, however, we propose that multiple ABPs, acting cooperatively, may be involved in the control of actin filament length. Cofilin and DNase I are two ABPs that have previously been demonstrated to form a ternary complex with actin in vitro. This is the first report to demonstrate their co-localisation in vivo, and differences in their distributions. Our observations strongly suggest a physiological role for higher order complexes of actin in regulation of cytoskeletal assembly during processes such as cell division.

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